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Now a study from scientists at the Broad Institute and Massachusetts General Hospital (MGH) reveals a novel compound that successfully but selectively blocks this response to oxidative stress in cancer cells, sparing normal cells. In fact, its effectiveness surpasses even a chemotherapy drug currently used for breast cancer.
The compound? It’s actually derived from the fruit of a pepper plant native to southern India and Southeast Asia, a compound called plant-based piperlongumine or PL. Cancer cells are killed by jamming the machinery that dissipates high oxidative stress and the resulting ROS. Because of their more modest metabolism, normal cells maintain low levels of ROS, making high levels of the anti-oxidant enzymes unnecessary once they pass a certain threshold.
Today, long pepper is a very rare ingredient in European cuisines, but it can still be found in Indian vegetable pickles, some North African spice mixtures, and in Indonesian and Malaysian cooking. It is readily available at Indian grocery stores, where it is usually labeled pippali.
We can supply the spices original from Indonesia, the name is Long Pepper or Piper retrofractum or Cabai Jawa/Cabai Jamu.